Integrated Services · RNAscope

RNAscope services for spatial RNA expression

Locate target RNA in individual cells while retaining tissue morphology. TriStar offers RNAscope RNA in situ hybridization for FFPE tissue sections and tissue microarrays, with pre-qualified samples and pathologist scoring to support your oncology research.

Discuss your RNAscope study
PPIB control staining in FFPE tissue
FFPE tissue · PPIB control

THE INTEGRATED SERVICES APPROACH

Samples, services and pathology expertise through one partner

Explore our repository

Repository samples

Selected for your study

ADD AS NEEDED

Assays & platform work

Additional biomarker characterization

Pathology guidance

Pharmaceutical research experience

Fewer handoffs
Spend less time coordinating samples and additional work across providers.
Pathology-informed decisions
Connect tissue suitability, assay selection and interpretation.
Coordinated sample use
Plan tissue allocation and laboratory work together, with one point of contact.

Connect RNA expression to tissue context

Investigate where a target is expressed and interpret the RNA signal alongside the surrounding tissue.

From expression to location

Put your target in context.

RNA in situ hybridization adds spatial information to your biomarker study, helping connect molecular findings with the cells and tissue regions that express the target.

Complement IHC findings

Compare RNA localization with protein-expression findings to support IHC assay optimization and target characterization.

Investigate targets without suitable antibodies

Assess target RNA directly in FFPE tissue when an appropriate antibody is not available for your study.

Localize transcriptomic findings

Examine where candidate targets identified through bulk transcriptomic analysis are expressed within tissue.

Pre-qualified tissue. Pathologist-led scoring.

Start with tissue assessed for RNA analysis and interpret the resulting signals with morphological context.

Tissue qualification

Controls that inform sample selection

RNAscope pre-qualified FFPE whole-tissue sections and TMAs are available with PPIB and DapB scoring information.

PPIBPositive-control signal
DapBNegative-control background
Pathologist review

RNA signals assessed at the cellular level

TriStar pathologists provide visual, semi-quantitative scoring based on RNA dots per cell, following ACD scoring criteria.

Cell-level assessmentSemi-quantitative scoringTissue morphology

RNAscope pre-qualified tissue collections

Explore whole-study starting points, from multi-tumor arrays to indication-specific and normal-tissue collections.

TA3117 & TA3118

Multi-tumor arrays

Two TMAs with 2 mm cores and histopathological data.

View collection
TA3168

Lung cancer

SCLC and NSCLC, including adenocarcinoma and squamous cell carcinoma; EGFR mutation status available for a subset.

View collection
TA4337 & TA4338

Normal, non-malignant tissue

Two TMAs with 2 mm cores for investigating expression across non-malignant tissues.

View collection
TA4321

Multi-tumor array with matched plasma

A pre-qualified multi-tumor array with histopathological data and matched plasma.

View collection

HBS & DONOR DATA

Quality biospecimens & data for precision medicine

UK · Italy · FranceDonors from participating medical centers, with informed consent and ethics approval.

FFPE surgical samplesPrimary tumors, metastases and normal (non-malignant) tissue.

Breadth of donor profiles

Specimen, treatment, outcomes and molecular data, structured at the patient level.

Patient trajectory

  • Primary tumors & matched distant metastases
  • Matched normal tissue
  • Neoadjuvant & adjuvant treatment
  • Standard-of-care targeted therapies & checkpoint inhibitors
  • Treatment regimen, line & dates
  • Responders & non-responders

Structured outcomes

  • Clinician-recorded response
  • Overall survival (months)
  • Progression-free survival (months)
  • Time to events (months)
  • Last follow-up
  • Event flags: recurrence / death / composite

Molecular characterization

  • IHC
  • FISH
  • RNA-ISH
  • NGS: SNVs, CNVs & fusions

Records are fully anonymized. Available fields vary by donor and reflect clinical practice at the source center. Cohorts are selected to meet your project’s requirements.

Explore early-stage, advanced and treatment-defined tissue cohorts with linked clinical and molecular data.

Explore tissue cohorts

Research & references

Research using TriStar tissue and data

Explore the research library

Organizations are identified from author affiliations, patent records and report credits. Their inclusion does not imply a partnership with or endorsement of TriStar.

Work with our experienced scientific team to tailor biospecimens, data, and integrated services to your research needs.

Our approach begins with our customers’ science.

We focus our acquisition on patient cohorts that meet the needs of biopharma, clinical, and translational researchers.

Scientist working with a pipette in a laboratory

Plan your study

Discuss your RNAscope study

Tell us your target, tissue type, sample count and required readout. Our team will review tissue selection, assay requirements and scoring for your project.

Discuss your study