High Quality Samples Yield
Reliable Results


TriStar has a twelve-year track record supporting the drug discovery and companion diagnostic activities of leading pharmaceutical companies


A Single Entity for Samples and Contract Research

Unmatched Collection Of High-Density Tissue Microarrays with RNA/DNA

Our strategically collected repository & collaborations enables us to create scientifically relevant high-density TMAs for biomarker research
  • Over 2.5 Million Archived Human Tumor Tissue Samples from Germany, Italy, Spain, U.K.
  • Extensive Follow Up and Molecular Data. Treatment, Response, Survival Information
  • Multi Tumor, Normal and Tumor-specific arrays,
  • RNAscope pre-qualified TMAs


Quality Control

  • 10% Buffered Formalin
  • SOPs governing tissue processing, fixation, TMA Manufacture
  • RNA (RIN), DNA Quality Control
  • RNAscope QC Assay

Ethical Considerations

  • Informed Donor Consent
  • IRB/EC approval
  • Fully Anonymized
  • Compliant with Current U.S. (HIPAA), International & EU Regulations





Immuno-oncology

TriStar samples for immuno-oncology are selected based on advancing tumor margin, qualitative assessment of inflammatory infiltrate (low/moderate/high)and PDL1 staining (Ventana SP-263) and include:

  • FFPE blocks from prevalent tumor types (NSCLC, Bladder, Head & Neck, Pancreatic, Gastric, TNBC, RCC etc.)
  • PD-L1 control FFPE blocks (positive or negative) with matched double spun plasma and follow up data

We can conduct studies of customer specified immune signatures using prevalent platforms and compared if required to other randomly selected FFPE samples
Hematological Cancers

Control FFPE Blocks

We screen thousands of FFPE blocks to identify ones that are positive or negative for selected markers.

Biomarkers include:
  • EGFR Mutations (Exon 19, 21, Variants)
  • KRAS Mutations (G12A, G12C, G12D, G12, G12V, G12R, G12S)
  • TIM3, LAG3, OX40, GITR, IDO1, PD-L1, PD-1 (IHC)
  • ALK (IHC)
  • MSI (IHC)
  • EGFR (amp)
  • HER2 (IHC & CISH)



Integrated Solutions

We offer a highly cost effective and time-efficient CRO model by integrating our samples with in-house analytical capabilities

  • IHC (Ventana Benchmark, Dako & Leica Bond)
  • RNA Scope
  • Sanger & NGS (Illumina MiSeq, ThermoFisher S5)
  • RTPCR
  • Assay Transfer and Development
  • Target Profiling in Tumor & Normal Samples


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Tissue Microarray Cascade

The cascade comprises one or more TMAs across 3 Levels or tiers and is designed to answer the following specific questions about Biomarker expression

  • Which tumors and normal tissues is the Biomarker expressed in?
  • Is the marker expressed in niche tumors?
  • Is the marker prognostically relevant?
  • Is there an association with relapse to SOC treatment?


Selective Biomarker Stratification

We have used sequencing and IHC in-house to stratify cohorts of samples for biomarker investigations and companion diagnostic development by our customers.

Examples
  • CRC with KRAS, EGFR, NRAS, PIK3CA, BRAF, MSI
  • Prostate cancers with PTEN (IHC & FISH).
  • NSCLC, Bladder, Gastric, Small Bowel Carcinoma & RCC with known mismatch repair status (MSH-2, MSH-6, MLH-1, PMS-2 - Ventana IHC).
  • NSCLC with PD-L1

Hematological Cancers

Our repository includes TMAs and FFPE blocks from the following indications;
  • Non-Hodgkins Lymphoma
  • Diffuse Large B-Cell Lymphoma (GCB/non-GCB)
  • Follicular Lymphoma
  • Mantle Cell Lymphoma
  • Myelodysplastic Syndromes
  • Chronic Lymphocytic Leukemia
  • Follow up and Molecular Data

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