Integrated Services · Spatial Profiling

Spatial profiling with clinically characterized tissue

Source clinically annotated FFPE tissue and TMAs from TriStar’s repository for your spatial study. Select the tissue, treatment groups and follow-up relevant to your research, with spatial profiling available as an additional service.

Published NSCLC cell-type maps comparing representative responder and non-responder cases
Spatial cell maps · AACR 2023

THE INTEGRATED SERVICES APPROACH

Samples, services and pathology expertise through one partner

Repository samples

Selected for your study

ADD AS NEEDED

Assays & platform work

Additional biomarker characterization

Pathology guidance

Pharmaceutical research experience

Fewer handoffs
Spend less time coordinating samples and additional work across providers.
Pathology-informed decisions
Connect tissue suitability, assay selection and interpretation.
Coordinated sample use
Plan tissue allocation and laboratory work together, with one point of contact.

SPATIAL BIOLOGY

Examine cell populations in their tissue context

Published NSCLC multiplex image showing CD68, CD8 and pan-cytokeratin
Representative NSCLC multiplex image from the AACR 2023 poster by TriStar- and Enable Medicine-affiliated authors. View publication citation.

Cell identity, location and clinical context

Spatial studies can examine how tumor, immune and stromal cells are organized. Clinically annotated tissue adds the treatment and follow-up information needed to define the study groups.

PROFILING OPTIONS

Add spatial readouts to the selected tissue

REGION-BASED PROFILING

GeoMx digital spatial profiling

Discuss protein or RNA measurements in defined tissue regions. Selected collections offer optional GeoMx datasets, allowing existing characterization to be reviewed before additional work is planned.

  • FFPE sections
  • TMAs
  • Protein or RNA panels

TISSUE & PATHOLOGY

Qualification and region selection

Review morphology, the tissue regions of interest and platform-specific quality requirements. Selected materials have RNAscope control scores or RNA DV200 information available.

  • Morphology review
  • PPIB / DapB controls
  • RNA quality information

TISSUE MICROARRAYS

Tissue microarrays for spatial study planning

Explore tissue microarrays (TMAs) for spatial studies. Donor matching and existing spatial data vary by array.

TMA · TA4301

NSCLC with IO follow-up

  • Optional GeoMx protein/RNA
  • Optional RNA-seq & IHC

Second-line immunotherapy follow-up with options for additional molecular datasets.

TMA · TA3111

Pre- / post-treatment NSCLC

  • Donor matched
  • Follow-up data

Paired pre- and post-treatment tissue from the same donors.

TMA · TA4330

Metastatic prostate cancer

  • RNAscope pre-qualified
  • Pre- / post-treatment groups

HRPC/CRPC tissue with follow-up. Pre- and post-treatment groups are not donor matched.

Research & references

Research using TriStar tissue and data

Explore the research library

Organizations are identified from author affiliations, patent records and report credits. Their inclusion does not imply a partnership with or endorsement of TriStar.

Work with our experienced scientific team to tailor biospecimens, data, and integrated services to your research needs.

Our approach begins with our customers’ science.

We focus our acquisition on patient cohorts that meet the needs of biopharma, clinical, and translational researchers.

Scientist working with a pipette in a laboratory

Plan your study

Select tissue for your spatial profiling study

Tell us the indication, tissue regions, comparison groups and number of cases you need. We’ll review suitable repository material and available characterization, with spatial profiling added to the scope as required.

Request a cohort