Integrated Services Digital Spatial Profiling

Digital Spatial Profiling

Understand tumor microenvironment heterogeneity with multi-omic spatial profiling of protein and/or RNA in FFPE whole tissues & TMAs.

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Digital spatial profiling using platforms such as the GeoMx Digital Spatial Profiler (DSP) delivers spatial transcriptomics & proteomics in a single slide. TriStar offers GeoMx DSP characterized TMAs & services to facilitate a deeper understanding of tumor & immune spatial biology.

Combine digital spatial profiling with TriStar’s targeted TMA collection including extensive clinical outcome (SOC/CKI) data to explore transcriptomic & protein signatures aligned to response/resistance/relapse.

Benefits of choosing Tristar’s services

Scientifically Relevant TMAs

Targeted TMA collection with extensive molecular & clinical follow up information, including SOC/CKI outcome data, to support oncology translational research programs.

4MD Pathologists

TriStar pathologists guide tissue collections, TMA construction, target analysis & interpretation.

NGS Services

Samples annotated using standard ThermoFisher & Illumina panels, Genexus & NovaSeq equipment. Reports can include TMB, HLA-DR, MSI, TCR and BCR.

FFPE tissues QC’d for RNA analyses

FFPE whole tissue sections & TMAs available with RNAscope QC (PPIB & dapB) and RNA DV200%.

Service Workflow

Define Your Project Requirements
We will sit down with you and work out exactly what the objective of your project is as well as the parameters to work within.
Sample Allocation
We will source the right samples from within our repositories and network.
Services Platform
We will put together the right team and platforms to complete your project correctly and on time.
Confirm & Start Project
A Statement of Work that includes a project plan, deliverables, costs and timelines will be discussed and agreed upon.

Suggested Products

TA4301-current

NSCLC with 2nd line IO follow up & optional RNAseq, GeoMx (protein & RNA panels), DAB IHC data (TA4301)

TA3111-record

NSCLC donor matched pre & post treatment samples with follow up data (TA3111)

Rectangle 20

Melanoma with IO (Pembro/Nivo) follow up data, pre treatment and post IO treatment (not donor matched)

TA4330-current

RNAscope prequalified metastatic HRPC/CRPC pre and post treatment (not donor matched) with follow up data (TA4330)

Related Services

NGS Services

Samples annotated using standard ThermoFisher & Illumina panels, Genexus & NovaSeq equipment. Reports can include TMB, HLA-DR, MSI, TCR and BCR.

Digital Image Analysis

Quantify and localize target expression across tumor types.

Publications

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Enable Medicine AACR 2023Apr-23

Single-cell spatial proteomic analysis of the tumor microenvironment in treatment-naive NSCLC samples with immunotherapy treatment and response data

University of Queensland, Australia ASCOJun-22

Multi-omic and spatial dissection of immunotherapy response groups in non-small cell lung cancer (NSCLC)