Research applications · Biomarker prevalence
Biomarker prevalence studies in oncology
Evaluate target expression across tumor and nonmalignant tissues with TriStar tissue microarrays and FFPE cohorts. Add IHC staining and pathology scoring for the tissue and patient groups relevant to your program.
From screening to focused investigation
Choose tissue around your research question
Across tumor types
Multi-tumor TMAs
Use multi-tumor tissue microarrays to survey target expression across cancer types and identify indications for further investigation.
In nonmalignant tissue
Normal-tissue TMAs
Use normal tissue microarrays to compare expression across nonmalignant tissues and examine staining patterns alongside your tumor findings.
Within an indication
Tumor-specific TMAs & FFPE cohorts
Investigate expression within a cancer type using histology, disease stage and available clinical or molecular data.
Expression frequency reflects the selected cohort, assay and scoring criteria. Biomarker-enriched cohorts should not be used to infer prevalence in an unselected population.
Selected arrays
Tissue microarrays for prevalence studies
Start with a broad expression survey or focus on a defined cancer cohort. Review each array’s tissue composition and available data before selecting it for your study.
MULTI-TUMOR SCREENING · TA4340
Multi tumor array comprising breast, bladder(uc), ovarian, lung, prostate, melanoma, RCC , head & neck SCC, CRC, pancreatic ADC with histopath data (TA4340)
- Approx. cores
- 120
- Approx. donors
- 120
- Core diameter
- 1mm
NONMALIGNANT TISSUE COMPARISON · TA3153
RNAscope pre-qualified Normal (non-malignant) samples, 1mm core diameter, ~32 tissue types, 3 donors each (TA3153)
- Approx. cores
- 105
- Approx. donors
- 105
- Core diameter
- 1mm
COLORECTAL · MSI & FOLLOW-UP · TA1114/01
CRC with follow up data, MSI status (TA1114/01)
- Approx. cores
- 148
- Approx. donors
- 148
- Core diameter
- 1mm
PROSTATE · DISEASE PROGRESSION · TA2573
Prostate cancer progression array with follow up data, includes normal, PIN, Gleason 6-10 (TA2573)
- Approx. cores
- 150
- Approx. donors
- 75
- Core diameter
- 1mm
Counts are approximate. Product details and datasheets describe the available case-level information and assay suitability.
Browse all TMAsStudy planning
Design a tissue biomarker prevalence study
Define the population, tissue format and scoring criteria together so the resulting expression data answer a specific research question.
Define the cohort
Specify tumor types, histologic subtypes and any biomarker selection criteria. Include nonmalignant tissue when the question concerns target distribution beyond the tumor. Record which donors are eligible for the analysis; a cohort selected for high expression cannot estimate prevalence in an unselected population.
Choose the tissue format
TMAs let you compare many tissue cores under a common staining workflow. Whole FFPE sections can complement an array when regional variation or broader tissue architecture matters. Distinguish the number of evaluable donors from the number of cores, especially when several cores represent one donor.
Agree on scoring and outputs
Plan the assay, cellular compartment and positivity threshold before comparing groups. Discuss intensity, percentage of positive cells and pathology scoring with TriStar. Define the required case-level scores, available images and cohort annotations in the project scope; report the evaluable denominator alongside any expression frequency.
For immune-cell context, explore immuno-oncology tissue research. For antibody target characterization, see ADC and bispecific research.
Assays & pathology support
Add assays around your study question
Select protein, RNA or multiplex measurements to complement your tissue cohort and available donor data.
Protein expression
IHC assay services
Measure target expression across selected tissues with IHC staining and pathology scoring, including intensity, proportion and tissue distribution.
Explore IHC servicesSpatial RNA expression
RNAscope RNA-ISH
Localize target RNA in FFPE tissue, with pre-qualified samples, assay controls and pathologist scoring.
Explore RNAscopeMultiplex protein imaging
Multiplex immunofluorescence
Investigate co-expression of protein targets within selected cell populations using multiplex immunofluorescence on FFPE tissue or TMAs.
Research & references
Research using TriStar tissue and data
Author affiliations
Seoul National University College of Medicine
TriStar Technology Group
Author affiliations
Bicycle Therapeutics
NeoGenomics
Organizations are identified from author affiliations, patent records and report credits. Their inclusion does not imply a partnership with or endorsement of TriStar.
Work with our experienced scientific team to tailor biospecimens, data, and integrated services to your research needs.
Our approach begins with our customers’ science.
We focus our acquisition on patient cohorts that meet the needs of biopharma, clinical, and translational researchers.
Plan your study
Discuss your biomarker prevalence study
Tell us your target, tumor and normal tissue requirements, number of cases and any staining or scoring you would like to add. We’ll review suitable TMAs, FFPE cohorts and the available data for your study.